Niels Fischer

Decoding the Sequence Requirements for Translation Initiation

The paper defines an extended translation initiation sequence (eTIS) and shows that a deep-learning model trained on eTIS features accurately predicts translation initiation, revealing that the Kozak sequence is not optimal and identifying conserved nucleotides that enhance initiation efficiency.

Selective silencing of antibiotic-tethered ribosomes as a resistance mechanism against aminoglycosides

The paper identifies a novel antibiotic resistance mechanism where fusA mutations slow ribosome movement when aminoglycosides are bound, preventing error cluster formation and maintaining bacterial growth.

Conformational rearrangements upon start codon recognition in human 48S translation initiation complex

The paper characterizes conformational changes in human 48S translation initiation complexes during start codon recognition using cryo-EM and kinetic methods.

Structural mechanism of GTPase-powered ribosome-tRNA movement

This study reveals how GTP hydrolysis by EF-G drives ribosome-tRNA movement through structural changes visualized by cryo-EM.

Structure and function of the intermembrane space domain of mammalian FoF1 ATP synthase

This study determines the structure and function of the intermembrane space domain in mammalian FoF1 ATP synthase using cryo-EM and biochemical analysis.