Narcolepsy with cataplexy is caused by epigenetic silencing of hypocretin neurons
Ali Seifinejad, Almar Neiteler, Sha Li, Corinne Pfister, Rolf Fronczek, Ling Shan, Lee Ann Garrett‐Sinha, David Frieser, Makoto Honda, Yoan Arribat, Dogan Grepper, Francesca Amati, Marie Picot, Christian Iseli, Nicolas Chartrel, , Mehdi Tafti
The paper shows that narcolepsy with cataplexy is caused by epigenetic silencing of hypocretin neurons, not their destruction, using QRFP as a marker and methylation analysis.
bioRxiv · Sep 21, 2021 · PreprintNeuroscience