Author

Ling Shan

Netherlands Institute for NeuroscienceORCID 0000-0002-4765-2474Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Rolf FronczekiD· 2 shared Ali SeifinejadiD· 1 shared Almar NeiteleriD· 1 shared Anne VassalliiD· 1 shared Christian IseliiD· 1 shared Corinne PfisteriD· 1 shared David FrieseriD· 1 shared Dick Frans SwaabiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersNeuroscience

Rolf FronczekORCID

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2 papers

Recent·Most cited

Increased numbers of CD4+ T-cells in hypocretin/orexin region of Narcolepsy Type 1

Ling Shan, Milo Fonville, Mabel Hoekstra, Rolf Fronczek, Joost Smolders, Dick Frans Swaab

The paper identifies an 11-fold increase in CD4+ T-cells in the hypocretin region of NT1 brains, correlating with symptom severity.

Annals of Neurology · Mar 14, 2026Peer-reviewedNeuroscience

Narcolepsy with cataplexy is caused by epigenetic silencing of hypocretin neurons

Ali Seifinejad, Almar Neiteler, Sha Li, Corinne Pfister, Rolf Fronczek, Ling Shan, Lee Ann Garrett‐Sinha, David Frieser, Makoto Honda, Yoan Arribat, Dogan Grepper, Francesca Amati, Marie Picot, Christian Iseli, Nicolas Chartrel, , Mehdi Tafti

The paper shows that narcolepsy with cataplexy is caused by epigenetic silencing of hypocretin neurons, not their destruction, using QRFP as a marker and methylation analysis.

bioRxiv · Sep 21, 2021 · PreprintNeuroscience