Christian Iseli

A minimal model of stable autocatalytic RNA-replication through integration of replication, molecular regulation, and energy conversion

This paper develops a minimal mathematical model showing how ATP-dependent allosteric regulation stabilizes RNA replication by taming parasitic mutants through hyperparasitic binding and evolutionary transitions in control and energy conversion.

A chromosome-level, haplotype-resolved genome assembly for the barn owl, Tyto alba

The paper presents a chromosome-level, haplotype-resolved genome assembly for the barn owl, resolving microchromosomes and enabling structural variation studies.

Biomathematical enzyme kinetics model of prebiotic autocatalytic RNA networks: degenerating parasite-specific hyperparasite catalysts confer parasite resistance and herald the birth of molecular immunity

The paper develops a biomathematical enzyme kinetics model of prebiotic autocatalytic RNA networks, showing that hyperparasites confer parasite resistance and explain the origin of molecular immunity.

Repairing a deleterious domestication variant in a floral regulator gene of tomato by base editing

This study repairs a harmful mutation in a tomato gene using base editing, resulting in plants with compact growth and earlier fruit yield.

Variant-specific pathophysiological mechanisms of AFF3 differently influence transcriptome profiles

The paper identifies variant-specific effects of AFF3 on transcriptome profiles through analysis of patient cohorts and zebrafish models, showing distinct pathophysiological mechanisms for different types of AFF3 variants.

Neighbouring modifications interfere with the detection of phosphorylated alpha-synuclein at Serine 129: Revisiting the specificity of pS129 antibodies

The paper shows that neighboring post-translational modifications affect the detection of phosphorylated alpha-synuclein at Serine 129 by existing antibodies.

Narcolepsy with cataplexy is caused by epigenetic silencing of hypocretin neurons

The paper shows that narcolepsy with cataplexy is caused by epigenetic silencing of hypocretin neurons, not their destruction, using QRFP as a marker and methylation analysis.

Estimating the Contribution of Proteasomal Spliced Peptides to the HLA-I Ligandome

The paper reanalyzes the contribution of proteasomal spliced peptides to the HLA-I ligandome and finds that only 2-4% of the ligandome may be explained by such peptides.