The paper links cognitive reserve to brain activity during memory formation, showing it moderates the impact of Alzheimer's pathology on cognitive performance and predicts slower decline.

Nature Communications · Nov 13, 2024Peer-reviewedNeuroscience

Neural adaptation at stimulus onset and speed of neural processing as critical contributors to speech comprehension independent of hearing threshold or age

Jakob Schirmer, Stephan Wolpert, Konrad Dapper, Moritz Rühle, Jakob Wertz, Marjoleen Wouters, Therese Eldh, Katharina Bader, Wibke Singer, Étienne Gaudrain, Deniz Başkent, Sarah Verhulst, Christoph Braun, Lukas Rüttiger, Matthias H. J. Munk, , Marlies Knipper

The paper investigates how neural adaptation and processing speed affect speech comprehension, showing these factors are critical even when hearing thresholds and age are controlled for.

Journal of Clinical Medicine · May 6, 2024Peer-reviewedNeuroscience

Fornix fractional anisotropy mediates the association between Mediterranean diet adherence and memory four years later in older adults without dementia

Adriana L. Ruiz‐Rizzo, Kathrin Finke, Jessica S. Damoiseaux, Claudia Bartels, Katharina Büerger, Nicoleta Carmen Cosma, Peter Dechent, Laura Dobisch, Michael Ewers, Klaus Fließbach, Ingo Frommann, Wenzel Glanz, Doreen Göerß, Stefan Hetzer, Enise Irem Incesoy, , the DELCODE study group

The paper examines if fractional anisotropy of the fornix mediates the link between Mediterranean diet adherence and verbal memory decline in older adults over four years.

Neurobiology of Aging · Feb 2, 2024Peer-reviewedNeuroscience

Phase coding in phoneme processing slows with age

Konrad Dapper, Jakob Schirmer, Lukas Rüttiger, Étienne Gaudrain, Deniz Başkent, Sarah Verhulst, Christoph Braun, Ernst Dalhoff, Stehpan M. Wolpert, Marlies Knipper, Matthias H. J. Munk

This study examines how age and hearing loss affect neural processing of phonemes, finding that temporal delay of EEG responses increases with age and high-frequency hearing loss, correlating with speech comprehension.

bioRxiv · Dec 22, 2023 · PreprintSystems Biology

Diagnostic images for mild cognitive impairment reveal biomarker status and abnormal scene processing

Yuetong Bai, Oliver Peters, Silka Dawn Freiesleben, Friederike Fenski, Josef Priller, Eike Jakob Spruth, Anja Schneider, Klaus Fließbach, Jens Wiltfang, Claudia Bartels, Ayda Rostamzadeh, Wenzel Glanz, Stefan Johannes Teipel, Ingo Kilimann, Christoph Laske, , Wilma Alice Bainbridge

The paper identifies diagnostic images that correlate with Alzheimer's biomarkers and show differential neural processing in MCI patients compared to healthy controls.

bioRxiv · Nov 30, 2023 · PreprintNeuroscience

Blood transcriptome analysis suggests an indirect molecular association of early life adversities and adult social anxiety disorder by immune-related signal transduction

Susanne Edelmann, Ariane Wiegand, Thomas Hentrich, Sarah Pasche, Julia Maria Schulze-Hentrich, Matthias H. J. Munk, Andreas Jochen Fallgatter, Benjamin Kreifelts, Vanessa Nieratschker

The paper identifies indirect molecular links between early life adversity and adult social anxiety disorder through immune-related signal transduction pathways using transcriptome analysis.

Frontiers in Psychiatry · Apr 25, 2023Peer-reviewedGenomics

Individualized Gaussian Process-based Prediction of Memory Performance and Biomarker Status in Ageing and Alzheimer's disease

Aditya Nemali, Niklas Vockert, David Berron, Anne Maaß, Renat Yakupov, Oliver Peters, Daria Gref, Nicoleta Carmen Cosma, Lukas Preis, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Andrea Lohse, Klaus Fließbach, Okka Kimmich, , Gabriel Ziegler

The paper uses Gaussian process multikernel modeling to predict memory performance and CSF biomarkers in ageing and Alzheimer's disease using MRI and other data.

bioRxiv · Mar 14, 2022 · PreprintNeuroscience