Quantitative Multicolored Deep Imaging of Human Bones Reveals a Composite Osteo-Sinusoidal Niche for Mesenchymal Stromal Cells.
Nelson Tsz Long Chu, Ostap A. Dregval, Yu‐Wei Chang, Emil Kryukov, Xin Tian, Xin Liu, Dana Trompet, Misty Shuo Zhang, Lei Li, Zhong Li, Emiliano Gómez-Ruiz, Joana B. Pereira, Mats Brittberg, Björn Barenius, Lars S Savendahl, , Andrei S. Chagin
The paper uses a tissue-clearing protocol to spatially map BM-MSCs in human bones, revealing distinct microenvironment features in young and aged bones.
bioRxiv · Oct 7, 2025 · PreprintCell Biology