Author

Joel T. Gabre

Columbia University Irving Medical CenterORCID 0000-0002-5347-3341Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Yosuke MitaniiD· 3 shared Ricardo Cruz‐AcuñaiD· 2 shared Tianxia LiiD· 2 shared Aleksandar ObradovićiD· 1 shared Alice E. ShiniD· 1 shared Beatrice Dionigi· 1 shared Caitlin Rogers· 1 shared Casidhe-Nicole R. Bethancourt· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersDevelopmental Biology

Yosuke MitaniORCID

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Author profile →

3 papers

Recent·Most cited

STAT3 regulates basal cell identity and morphogenesis during early esophageal development

Secunda W. Kariuki, Yosuke Mitani, Dominique D. Bailey, Gizem Efe, Halil Tekin, Ved V. Tripathi, Kensuke Suzuki, James Michael Wells, Jianwen Que, Joel T. Gabre, Ricardo Cruz‐Acuña

This study shows STAT3 is essential for esophageal progenitor cell development and epithelial morphogenesis in humans, but not in mice.

bioRxiv · Aug 1, 2025 · PreprintDevelopmental Biology

Single-Cell RNA Sequencing and Inferred Protein Activity Analysis Reveal a Distinct Tumor Phenotype in Early-Onset Colorectal Cancer Patients

David A. Cohen, Aleksandar Obradović, Luka Jovanovic, Yosuke Mitani, Tianxia Li, Soobeom Lee, Dechokyab De, Casidhe-Nicole R. Bethancourt, Alice E. Shin, Karen J. Dunbar, Francesco Cambuli, Christopher J. Lengner, Ning Li, Caitlin Rogers, Jennifer Ho, , Joel T. Gabre

The paper compares early-onset and late-onset colorectal cancer using scRNA-seq and VIPER to identify distinct stromal and epithelial features in early-onset tumors.

bioRxiv · May 15, 2025 · PreprintCancer Biology

EPHA2 Regulates SOX2 during Esophageal Development

Tianxia Li, Yosuke Mitani, Ricardo Cruz‐Acuña, Tatiana A. Karaksheva, Varun Sahu, Cecilia Martin, Hiroshi Nakagawa, Joel T. Gabre

This study shows that EPHA2 regulates SOX2 expression during human esophageal development using iPSCs and organoids, with EPHA2 inhibition reducing SOX2 levels and organoid formation.

bioRxiv · Oct 8, 2024 · PreprintDevelopmental Biology