Christopher J. Lengner

The paper presents the Human Gut Cell Atlas v1.0, a unified reference of gut cell diversity, revealing how tissue structure influences cellular composition and enabling disease and organoid analysis.

The paper identifies MAIT cell enrichment in Lynch syndrome carriers without CRC, linked to immune surveillance and reduced cancer risk.

This study identifies SETD8 as a target of APC-coordinated GSK3 phosphorylation in colorectal cancer, showing that phosphorylation suppresses SETD8's oncogenic activity.

The paper identifies an inflammatory secretory progenitor cell state in Crohn's disease patients and shows its epigenetic regulation in stem cells.

The paper investigates Xist RNA localization patterns in female progenitor cells from different tissues, showing tissue-specific and NF-kappaB-independent mechanisms of X chromosome inactivation.

The paper compares early-onset and late-onset colorectal cancer using scRNA-seq and VIPER to identify distinct stromal and epithelial features in early-onset tumors.

This study identifies that APC loss in colorectal cancer drives a β-CATENIN-independent fetal intestinal transcriptional program through YAP activation, leading to bistable stem cell states and enhanced tumorigenesis.

FLASH proton radiotherapy improves normal tissue toxicity without compromising anti-tumor efficacy by coordinating IFN-I signaling across stromal, immune, and revSC networks.

The paper identifies Sox9 as a marker for limbal stem cells and shows its requirement for asymmetric cell fate switch in the corneal epithelium.

This paper demonstrates the orthotopic transplantation of human induced pluripotent stem cell-derived alveolar progenitor cells into murine lungs to create a humanized lung model.