Karen J. Dunbar

This study shows that molecular glue degraders targeting CK1 can co-degrade multiple SACK1 proteins, highlighting the role of protein complex context in targeted protein degradation.

This study identifies HMMR's role in stabilizing the SACK1D-CK1 complex at the mitotic spindle and shows how phosphorylation drives its degradation after mitosis.

The paper compares early-onset and late-onset colorectal cancer using scRNA-seq and VIPER to identify distinct stromal and epithelial features in early-onset tumors.