Temozolomide-associated inflammatory-repair remodeling in recurrent glioblastoma exposes a ROCK-linked therapeutic vulnerability
Rafał Chojak, Umme Habiba Faisal, Priya Kumthekar, Noah B. Drewes, Lara Koutah, Jessica Jia, Jillyn R Turunen, Maeve C. O’Shea, Victoria Falkowski, Ayaan Akhtar, Shu Wang, Justin Chen, Shanti Ahmed, Hasaan A Kazi, Brenda Auffinger, , Atique U. Ahmed
This study shows that preoperative temozolomide exposure in recurrent glioblastoma leads to inflammatory-repair remodeling and a ROCK-linked therapeutic vulnerability, which can be targeted by fasudil.
bioRxiv · Sep 22, 2026 · PreprintCancer Biology