Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
Abhinav Dhall, Alyssa Pyclik, Matthew H. Ung, Julia Etchin, Yonina Keschner, Huanying Gary Ge, Tirtha Chakraborty, John R. Lydeard
The paper develops a proteogenomic framework to identify dispensable genes for safer gene editing in hematopoietic therapies, identifying 237 candidates including LY75.
bioRxiv · Dec 17, 2025 · PreprintGenetics
Antonino Montalbano, Huan Qiu, Lakshmi Karthik, Sawyer Letourneau, Jianxin Hu, Tirtha Chakraborty, Huanying Gary Ge, John R. Lydeard, Ruijia Wang, Eric Gunnar Anderson
The paper identifies sequencing artifacts in gRNA purity assessment and introduces FUSS-seq to reduce them, improving accuracy for CRISPR-based therapeutics.
bioRxiv · Sep 13, 2025 · PreprintMolecular Biology
Yonina Keschner, Julia Etchin, Mariana Camoesas Silva, Hannah Mager, Hillary Hoyt, Juliana M. Xavier-Ferrucio, Nathan A. Manalo, Amanda L. Halfond, Huan Qiu, Ruijia Wang, Michelle I. Lin, Huanying Gary Ge, Julian Scherer, Tirtha Chakraborty, John R. Lydeard
This study evaluates ADGRE2 as an AML target, showing efficient gene editing in HSPCs to protect against myelotoxicity and developing ADGRE2-specific CAR T cells for therapy.
bioRxiv · Aug 21, 2025 · PreprintCancer Biology
Matthew H. Ung, Gabriella Angelini, Ruijia Wang, Alyssa Pyclik, John R. Lydeard, Juliana M. Xavier-Ferrucio, Michelle I. Lin, Tirtha Chakraborty, Huanying Gary Ge
The paper constructs a single-cell DNA sequencing atlas and introduces GUMM, a computational workflow, to accurately infer gene editing allelism despite technical artifacts.
bioRxiv · May 22, 2025 · PreprintBioinformatics
Huan Qiu, Ruijia Wang, Shu Wang, Aymen Maqsood Mulbagal, Eric Anderson, Huanying Gary Ge
SANTON is a toolkit for analyzing off-target sequencing data from gene-editing technologies, identifying more potential off-target sites than previous studies.
bioRxiv · May 9, 2025 · PreprintBioinformatics