Author

Wenbo Guo

Tsinghua UniversityORCID 0000-0002-5367-619XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Bing ZhangiD· 1 shared Bowen WangiD· 1 shared Dan WangiD· 1 shared Haixia YangiD· 1 shared Hanqing HeiD· 1 shared Hudong Bao· 1 shared Jie LiaoiD· 1 shared Jin GuiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBioinformatics

Bing ZhangORCID

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2 papers

Recent·Most cited

Pharmacological Induction of Irreversible Senescence in Drug-Tolerant Persister Cells Prevents Tumor Relapse

Bowen Wang, Yun Zhi, Pengqi Wang, Wenbo Guo, Jin Gu, Hanqing He, Kezhang He, Wei Zhou, Ting Wang, Nana Huang, Haixia Yang, Dan Wang, Tianhua Ma, Sheng Ding

This paper identifies a drug combination that irreversibly senesces drug-tolerant persister cells, preventing tumor relapse in melanoma models.

bioRxiv · Oct 10, 2025 · PreprintCancer Biology

Reconstruction of the cell pseudo-space from single-cell RNA sequencing data with scSpace

Jie Liao, Jingyang Qian, Ziqi Liu, Ying Chi, Yanrong Zheng, Xin Shao, Junyun Cheng, Yongjin Cui, Wenbo Guo, Penghui Yang, Yining Hu, Hudong Bao, Qian Chen, Mingxiao Li, Bing Zhang, Xiaohui Fan

scSpace reconstructs a pseudo-space from single-cell RNA-seq data to identify spatially variable cell subclusters and their biological relevance.

bioRxiv · May 7, 2022 · PreprintBioinformatics