NOTUM-MEDIATED WNT SILENCING DRIVES EXTRAVILLOUS TROPHOBLAST CELL LINEAGE DEVELOPMENT
Vinay Shukla, Ayelen Moreno‐Irusta, Kaela M. Varberg, Marija Kuna, Khursheed Iqbal, Anna M. Galligos, John Aplin, Ruhul Choudhury, Hiroaki Okae, Takahiro Arima, Michael J. Soares
This study shows that NOTUM downregulates WNT signaling to drive EVT cell differentiation from human trophoblast stem cells, essential for placental development and healthy pregnancy.
Proceedings of the National Academy of Sciences · Sep 26, 2024Peer-reviewedDevelopmental Biology