Hiroaki Okae

This study identifies PPARG as a critical regulator of trophoblast cell differentiation and uterine-placental interface formation in both human and rat models.

This study shows that NOTUM downregulates WNT signaling to drive EVT cell differentiation from human trophoblast stem cells, essential for placental development and healthy pregnancy.

This study investigates how AHR ligand TCDD affects human trophoblast cell development and differentiation, finding altered gene expression and increased 2ME production without hindering stemness or differentiation.

This study shows BCOR is essential for syncytiotrophoblast differentiation in mice and humans by repressing stem cell genes and alternate lineage factors.

This study identifies endogenous retroviruses that regulate trophoblast gene expression in humans, with implications for pregnancy outcomes.

This study investigates the role of CITED2 in regulating the uterine-placental interface in rat and human models, showing its critical role in trophoblast cell development and placental function.

This study identifies PKCλ/ι as essential for trophoblast progenitor differentiation into syncytiotrophoblast cells during placentation in both mice and humans.