This study investigates the role of endothelin signaling in auditory development using mouse models of Waardenburg-Shah syndrome, revealing distinct contributions from neural crest and placode lineages.

iScience · Dec 24, 2024Peer-reviewedDevelopmental Biology

Lineage-specific intersection of endothelin and GDNF signaling in enteric nervous system development

Denise M Poltavski, Alexander T. Cunha, Jaime Tan, Henry M. Sucov, Takako Makita

The paper shows that two distinct ENS progenitor lineages use endothelin signaling differently to support migration to the hindgut.

eLife · Dec 6, 2024Peer-reviewedDevelopmental Biology

CITED2 is a Conserved Regulator of the Uterine-Placental Interface

Marija Kuna, Pramod Dhakal, Khursheed Iqbal, Esteban Mauricio Dominguez, Lindsey N. Kent, Masanaga Muto, Ayelen Moreno‐Irusta, Keisuke Kozai, Kaela M. Varberg, Hiroaki Okae, Takahiro Arima, Henry M. Sucov, Michael J. Soares

This study investigates the role of CITED2 in regulating the uterine-placental interface in rat and human models, showing its critical role in trophoblast cell development and placental function.

Proceedings of the National Academy of Sciences · Jan 10, 2023Peer-reviewedDevelopmental Biology

Purkinje cardiomyocytes of the ventricular conduction system are highly diploid but not regenerative

Hirofumi Watanabe, Ge Tao, Peiheng Gan, Baylee C. Westbury, Kristie D. Cox, Kelsey Tjen, Ruolan Song, Glenn I. Fishman, Takako Makita, Henry M. Sucov

The paper identifies Purkinje cardiomyocytes as a diploid subpopulation in the ventricular conduction system that lacks regenerative capacity despite their diploid status.

bioRxiv · Oct 29, 2022 · PreprintDevelopmental Biology