Khursheed Iqbal

PPARG directs trophoblast cell fate and establishment of the uterine-placental interface

This study identifies PPARG as a critical regulator of trophoblast cell differentiation and uterine-placental interface formation in both human and rat models.

TFAP2C is a key regulator of intrauterine trophoblast cell invasion and deep hemochorial placentation

This study identifies TFAP2C as a critical regulator of trophoblast cell invasion and hemochorial placentation in rats, showing its role in both early development and later gestation.

NOTUM-MEDIATED WNT SILENCING DRIVES EXTRAVILLOUS TROPHOBLAST CELL LINEAGE DEVELOPMENT

This study shows that NOTUM downregulates WNT signaling to drive EVT cell differentiation from human trophoblast stem cells, essential for placental development and healthy pregnancy.

Effects Of Aryl Hydrocarbon Receptor Ligand TCDD On Human Trophoblast Cell Development

This study investigates how AHR ligand TCDD affects human trophoblast cell development and differentiation, finding altered gene expression and increased 2ME production without hindering stemness or differentiation.

TAF7L REGULATES EARLY STAGES OF MALE GERM CELL DEVELOPMENT

This study shows that TAF7L is essential for male germ cell development in rats, leading to infertility due to meiotic arrest and failed sperm production.

CONDITIONALLY MUTANT ANIMAL MODEL FOR INVESTIGATING THE INVASIVE TROPHOBLAST CELL LINEAGE

This paper develops a conditional rat model to study invasive trophoblast cell lineage regulation and its role in uterine spiral artery remodeling.

CORE CONSERVED TRANSCRIPTIONAL REGULATORY NETWORKS DEFINE THE INVASIVE TROPHOBLAST CELL LINEAGE

The paper compares chromatin accessibility and gene regulatory networks in invasive trophoblast cells between rat and human to identify conserved regulatory mechanisms.

CITED2 is a Conserved Regulator of the Uterine-Placental Interface

This study investigates the role of CITED2 in regulating the uterine-placental interface in rat and human models, showing its critical role in trophoblast cell development and placental function.

AKT1-FOXO4 AXIS RECIPROACLLY REGULATES HEMOCHORIAL PLACENTATION

The paper uses genome-edited rat models to show AKT1 and FOXO4 reciprocally regulate hemochorial placenta development.

Conservation at the uterine-placental interface

This study identifies conserved transcriptomic features of invasive trophoblast cells in rat and human placentation, providing insights into shared regulatory mechanisms essential for healthy pregnancy.