Neuronal late endosomes serve as selective RNA hubs disrupted by ALS-linked FUS mutation
Adriano Setti, Lorenzo Stufera Mecarelli, Tiziana Santini, Angelo D’Angelo, Vittorio Padovano, Erika Vitiello, Francesco Castagnetti, Julie Martone, Davide Mariani, Irene Bozzoni
The paper identifies late endosomes as selective RNA carriers in motor neurons and shows that ALS-linked FUS mutations disrupt this process.
Cell Reports · Oct 29, 2026Peer-reviewedMolecular Biology