Author

Colleen M. Pike

University of DelawareORCID 0000-0002-5409-2700Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Abby E. Richardson· 1 shared Abigail BoltiD· 1 shared Arthur S. McMillaniD· 1 shared Bailey Zwarycz· 1 shared C. Winfield PerkinsiD· 1 shared Casey M. TheriotiD· 1 shared Elizabeth M. BoazakiD· 1 shared Jacob Johnson· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperMicrobiology

Abby E. Richardson

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Systematic Discovery of Novel Phosphoinositide-Binding Effectors in Legionella Reveals Conserved α-Helical Folds

Abigail Bolt, Abby E. Richardson, Colleen M. Pike, Rebecca R. Noll, Yanbao Yu, Joshua P. Neunuebel, Sylvain LeMarchand, Karl R. Schmitz, M. Ramona Neunuebel

The paper identifies 33 novel phosphoinositide-binding effectors from three intracellular pathogens, revealing conserved α-helical structural motifs distinct from eukaryotic lipid-binding domains.

Microbiology Spectrum · Jul 1, 2026Peer-reviewedMicrobiology

Clostridioides difficile Toxins Alter Host Metabolic Pathway and Bile Acid Homeostasis Gene Expression In Colonic Epithelium

Stéphanie Thomas, Colleen M. Pike, C. Winfield Perkins, S. Brown, Xochilt M. Espinoza Jaen, Arthur S. McMillan, Casey M. Theriot

This study shows that C. difficile toxins alter host gene expression related to metabolic pathways and bile acid homeostasis in colonic epithelial cells.

Infection and Immunity · Jun 30, 2025Peer-reviewedMicrobiology

High-Throughput Assay for Predicting Diarrhea Risk Using a 2D Human Intestinal Stem Cell-Derived Model

Colleen M. Pike, James A. Levi, Lauren A. Boone, Swetha Peddibhotla, Jacob Johnson, Bailey Zwarycz, Maureen K. Bunger, William R. Thelin, Elizabeth M. Boazak

This paper develops a high-throughput assay using human intestinal stem cells to predict diarrhea risk from chemotherapeutics with high accuracy.

Toxicology in Vitro · Mar 12, 2025Peer-reviewedPharmacology & Toxicology