ImmunologybioRxivPreprint
A novel IL-1β reporter assay identifies tolcapone as a caspase-1 suppressor targeting pyroptosis in endotoxemia
Gabriela N. Chirițoiu, Simona Ghenea, Gheorghița Isvoranu…·Marioara Chiritoiu‐Butnaru
The paper develops a CRISPR-based IL-1β reporter assay to identify tolcapone as a caspase-1 inhibitor that suppresses pyroptosis in endotoxemia.
DOI 10.64898/2026.07.17.739124