Author

Gabriela N. Chirițoiu

Institute of BiochemistryORCID 0000-0002-6321-6373Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Cristian V. A. MunteanuiD· 3 shared Simona GheneaiD· 2 shared Stefana Maria PetrescuiD· 2 shared Alba Duran-Cortines· 1 shared Almudena Escobar-NiñoiD· 1 shared Ana Montero‐CalleiD· 1 shared Andrea LiaiD· 1 shared Andreas BenderiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBioinformatics

Cristian V. A. MunteanuORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintAug 20, 2026

A generalizable normalization framework to decouple protocol and instrument effects: Application to high-sensitivity proteomics multicentric study (PME13)

Gianluca Arauz‐Garofalo, Sergio Ciordia, Anne Gonzalez de Peredo…·Fernando José Corrales

This paper introduces a normalization framework to decouple protocol and instrument effects in multicenter proteomics studies, demonstrating its application to the PME13 dataset.

DOI 10.64898/2026.08.16.744113

proteomicsstatistical model

𝕏 PostBluesky

ImmunologybioRxivPreprintJul 21, 2026

A novel IL-1β reporter assay identifies tolcapone as a caspase-1 suppressor targeting pyroptosis in endotoxemia

Gabriela N. Chirițoiu, Simona Ghenea, Gheorghița Isvoranu…·Marioara Chiritoiu‐Butnaru

The paper develops a CRISPR-based IL-1β reporter assay to identify tolcapone as a caspase-1 inhibitor that suppresses pyroptosis in endotoxemia.

DOI 10.64898/2026.07.17.739124

humanproteomics

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BiochemistrybioRxivPreprintJan 29, 2025

C-terminal domain mobility underpins substrate engagement by the Chaetomium thermophilum EDEM:PDI ERAD-L checkpoint complex

Charlie J. Hitchman, Andrea Lia, Mohammed Bhogadia…·Pietro Roversi

The paper determines Cryo-EM structures of the EDEM:PDI complex with and without a substrate, revealing how disulfide bonds regulate conformational changes essential for substrate engagement.

DOI 10.1101/2025.01.29.635535

cryo-EMexperimental assay

𝕏 PostBluesky