Author

Simona Ghenea

Institute of BiochemistryORCID 0000-0002-5566-0335Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Cristian V. A. MunteanuiD· 2 shared Gabriela N. ChirițoiuiD· 2 shared Stefana Maria PetrescuiD· 2 shared Andrea LiaiD· 1 shared Andreas BenderiD· 1 shared Andrew QuigleyiD· 1 shared Angelo SantinoiD· 1 shared Bibek GooptuiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

Cristian V. A. MunteanuORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ImmunologybioRxivPreprintJul 21, 2026

A novel IL-1β reporter assay identifies tolcapone as a caspase-1 suppressor targeting pyroptosis in endotoxemia

Gabriela N. Chirițoiu, Simona Ghenea, Gheorghița Isvoranu…·Marioara Chiritoiu‐Butnaru

The paper develops a CRISPR-based IL-1β reporter assay to identify tolcapone as a caspase-1 inhibitor that suppresses pyroptosis in endotoxemia.

DOI 10.64898/2026.07.17.739124

humanproteomics

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BiochemistrybioRxivPreprintJan 29, 2025

C-terminal domain mobility underpins substrate engagement by the Chaetomium thermophilum EDEM:PDI ERAD-L checkpoint complex

Charlie J. Hitchman, Andrea Lia, Mohammed Bhogadia…·Pietro Roversi

The paper determines Cryo-EM structures of the EDEM:PDI complex with and without a substrate, revealing how disulfide bonds regulate conformational changes essential for substrate engagement.

DOI 10.1101/2025.01.29.635535

cryo-EMexperimental assay

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BioinformaticsbioRxivPreprintNov 1, 2022

Drug prediction for reversing AD/PD transcriptional profiles using an aging of systems-centric approach

Gabriela Bunu, Dmitri Toren, Eugen Ursu…·Robi Tăcutu

This study investigates the similarity between transcriptional changes in healthy aging and age-related diseases to predict drugs that could reverse these common patterns.

DOI 10.1101/2022.11.01.514657

humanbulk RNA-seq

𝕏 PostBluesky