Jacques Côté

This study investigates the MBTD1-EZHIP fusion protein in LGESS, showing it forms a TIP60-PRC2 complex, reduces H3K27me3, and upregulates oncogenes, similar to JAZF1-SUZ12 but with distinct mechanisms.

This study investigates how NuA4/TIP60 complex acetylates and loads H2A.Z onto chromatin to regulate transcription, showing that acetylation precedes chromatin incorporation at promoters.

This study shows Sfp1 and NuA4 interact in a TORC1-dependent manner to regulate ribosome biogenesis gene transcription through distinct mechanisms.

This paper characterizes the ZMYND11-MBTD1 fusion protein's role in oncogenesis by mislocalizing the NuA4/TIP60 complex to gene bodies, altering transcription and splicing, particularly of the MYC oncogene.

The paper identifies and characterizes multiple protein complexes associated with MRG15 and MRGX, revealing their roles in chromatin modification and transcription regulation.

This study shows RAP1 modulates TIP60/p400 complex activity to regulate gene expression, increasing 2-cell-like cells in mouse embryonic stem cells.

The paper identifies DNA damage-induced phosphorylation of histone H2A at serine 15 in yeast, linking it to DNA end resection and showing functional conservation with mammalian H2AK15 modifications.

This paper investigates the antagonistic relationship between the NuA4 complex and NHEJ factors in DNA repair, showing NuA4 promotes HR by facilitating end resection and inhibiting NHEJ.

This study shows NuA4 and SAGA acetyltransferase complexes cooperate to enable DNA break repair via homologous recombination by modulating nucleosome dynamics and facilitating end resection and strand invasion.

This study identifies recurrent chromosomal translocations in sarcomas that merge NuA4/TIP60 and PRC2 complexes, leading to mislocalization of chromatin marks and aberrant gene expression.

This study identifies Ubp15 as a deubiquitylase that couples transcription to mRNA export by regulating the ubiquitylation of Mex67 and its interaction with THO in yeast.

The paper shows that the NuA4 complex controls nuclear-encoded photosynthesis genes in Arabidopsis, with loss of key components leading to chloroplast dysfunction and reduced chlorophyll levels.