Jui M. Dave

This study identifies SPHK1 as a key driver of SMC hyperproliferation in elastin deficiency, showing its role in both pathological and physiological arterial remodeling.

The paper develops a statistical framework, SPRAWL, to detect subcellular RNA localization and alternative 3' UTR regulation in mouse brain and liver cells, finding correlations between 3' UTR length and localization.

The paper identifies novel regulatory elements and chromatin changes in human coronary artery smooth muscle cells during phenotypic switching, linking them to cardiovascular disease-associated SNPs and signaling pathways.

This study shows that deleting Psen1 in smooth muscle cells reduces Notch activity and improves elastin aortopathy in mice.