Author

Lisandro Horacio Otero

Consejo Nacional de Investigaciones Científicas y TécnicasORCID 0000-0002-5448-5483Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:protein structure prediction· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Alejandro Ezequiel CristófaloiD· 1 shared Arvind SharmaiD· 1 shared Fernando Alberto GoldbaumiD· 1 shared Kedar SharmaiD· 1 shared María Laura CeruttiiD· 1 shared Mario Juan BorgniaiD· 1 shared Roberto MeleroiD· 1 shared Romina Paola Pardo· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperImmunology

Alejandro Ezequiel CristófaloORCID

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1 paper

Recent·Most cited

ImmunologyProtein SciencePeer-reviewedMay 24, 2025

Cryo-EM structures of engineered Shiga toxin-based immunogens capable of eliciting neutralizing antibodies with therapeutic potential against Hemolytic Uremic Syndrome

Alejandro Ezequiel Cristófalo, Arvind Sharma, María Laura Cerutti…·Lisandro Horacio Otero

This paper presents cryo-EM structures of engineered Shiga toxin-based immunogens that stabilize pentamers and show interaction with neutralizing antibodies, supporting their use in a vaccine for STEC-HUS.

5 citations

E. colicryo-EM

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