Author

Arvind Sharma

Centre National de la Recherche ScientifiqueORCID 0000-0002-7029-9867Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Alejandro Ezequiel CristófaloiD· 1 shared Annalisa MeolaiD· 1 shared Charlie GosseiD· 1 shared Claire ValotteauiD· 1 shared Dorota N. KostrziD· 1 shared Eduard BaqueroiD· 1 shared Felix Augusto ReyiD· 1 shared Félix RicoiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperImmunology

Alejandro Ezequiel CristófaloORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Modulation of SARS-CoV-2 spike binding to ACE2 throughconformational selection

Prithwidip Saha, Ignacio Fernandez, Fidan Sumbul, Claire Valotteau, Dorota N. Kostrz, Annalisa Meola, Eduard Baquero, Arvind Sharma, James R. Portman, François Stransky, Thomas Boudier, Pablo Guardado‐Calvo, Charlie Gosse, Terence R. Strick, Felix Augusto Rey, Félix Rico

This study uses single-molecule techniques to show that SARS-CoV-2 spike protein RBD dynamics modulate ACE2 binding through conformational selection without affecting unbinding.

Nature Nanotechnology · Jun 10, 2025Peer-reviewedBiophysics

Cryo-EM structures of engineered Shiga toxin-based immunogens capable of eliciting neutralizing antibodies with therapeutic potential against Hemolytic Uremic Syndrome

Alejandro Ezequiel Cristófalo, Arvind Sharma, María Laura Cerutti, Kedar Sharma, Roberto Melero, Romina Paola Pardo, Fernando Alberto Goldbaum, Mario Juan Borgnia, Vanesa Zylberman, Lisandro Horacio Otero

This paper presents cryo-EM structures of engineered Shiga toxin-based immunogens that stabilize pentamers and show interaction with neutralizing antibodies, supporting their use in a vaccine for STEC-HUS.

Protein Science · May 24, 2025Peer-reviewedImmunology