Roberto Melero

This study identifies VDAC2 as a regulator of BAX activation by stabilizing a primed, membrane-inserted intermediate in the BAX activation pathway.

This study compares extracellular vesicles (EVs) and mechanically induced vesicles (MVs) for membrane protein structure determination, finding that MVs provide better structural representation of HER2 in native environments.

This study determines the structure of TbAQP2 bound to drugs and glycerol, revealing how mutations in the channel lead to drug resistance in Trypanosoma brucei.

This paper presents cryo-EM structures of engineered Shiga toxin-based immunogens that stabilize pentamers and show interaction with neutralizing antibodies, supporting their use in a vaccine for STEC-HUS.

The paper investigates the structural and functional impact of the S:A222V mutation in SARS-CoV-2, showing increased RBD opening and ACE2 binding without reducing neutralization capacity.

The paper analyzes the conformational dynamics of SARS-CoV-2 Spike prefusion structures using advanced cryo-EM data and reveals a continuous flexibility space rather than discrete states.

This work introduces a soft-alignment validation method to assess alignment precision, accuracy, and data homogeneity in cryo-EM single particle analysis, improving map resolution through data quality enhancement.