Extensive mosaicism by somatic L1 retrotransposition in normal human cells
Chang Hyun Nam, Jeonghwan Youk, Jeong Yeon Kim, Joonoh Lim, Jung Woo Park, Soo Ah Oh, Hyun Jung Lee, Hyein Won, Dong-Sung Lee, Seung‐Yong Jeong, Ji Won Oh, Jinju Han, Junehawk Lee, Hyun Woo Kwon, Min Jung Kim, Young Seok Ju
The paper analyzes somatic L1 retrotranspositions in single-cell genomes from normal human tissues, finding high prevalence in colorectal cells and revealing epigenetic mechanisms driving retrotransposition.
Nature · May 10, 2023Peer-reviewedGenomics