Joonoh Lim

Clonal dynamics of monozygotic twinning in early human embryogenesis

The paper uses post-zygotic mutations to analyze clonal dynamics in monozygotic twins and finds three clonal categories correlated with amnionicity, not chorionicity.

Trio-Based Whole-Genome Sequencing for Critically Ill Pediatric Patients in Korea

This study applies trio-based whole-genome sequencing in critically ill pediatric patients, achieving a 55% diagnostic yield and impacting patient management.

APOBEC3A, not APOBEC3B, drives deaminase mutagenesis in human gastric epithelium

This study shows APOBEC3A, not APOBEC3B, causes significant mutagenesis in human gastric epithelium through whole-genome sequencing of organoids with inducible APOBEC3A or APOBEC3B.

Target-enhanced whole-genome sequencing (TE-WGS) shows clinical validity equivalent to commercially available targeted oncology panel

This study compares target-enhanced whole-genome sequencing (TE-WGS) with a commercial targeted panel, showing TE-WGS detects all variants and provides additional clinical insights.

Clinical application of whole-genome sequencing for precision oncology of solid tumors

This study evaluates the clinical utility of whole-genome sequencing in solid tumors, showing 72% of reports provided clinically relevant insights and 69% aided therapeutic decision-making.

Extensive mosaicism by somatic L1 retrotransposition in normal human cells

The paper analyzes somatic L1 retrotranspositions in single-cell genomes from normal human tissues, finding high prevalence in colorectal cells and revealing epigenetic mechanisms driving retrotransposition.

Clonal dynamics in early human embryogenesis inferred from somatic mutation

This study uses somatic mutations to reconstruct cellular phylogenetic trees and analyze clonal dynamics in early human embryogenesis.

Mutational impact and signature of ionizing radiation

The paper investigates the mutational impact of ionizing radiation on normal cells and confirms these signatures in IR-induced cancers.