Jung Woo Park

The paper uses post-zygotic mutations to analyze clonal dynamics in monozygotic twins and finds three clonal categories correlated with amnionicity, not chorionicity.

This study estimates thermodynamic parameters for RNA/DNA hybrid duplexes using MD simulations, finding MMGBSA provides more accurate predictions than MMPBSA for modified oligonucleotides.

This study shows APOBEC3A, not APOBEC3B, causes significant mutagenesis in human gastric epithelium through whole-genome sequencing of organoids with inducible APOBEC3A or APOBEC3B.

The paper analyzes somatic L1 retrotranspositions in single-cell genomes from normal human tissues, finding high prevalence in colorectal cells and revealing epigenetic mechanisms driving retrotransposition.

ETCHING is an ultra-fast somatic structural variation caller that reduces mapping costs and false positives using pan-genome k-mer sets and a Random Forest classifier.

The paper shows that deleting Neuroligin-2 from specific neurons disrupts synaptic excitation-inhibition balance, causing lethality, while deleting it from both neuron types allows survival.

This study uses somatic mutations to reconstruct cellular phylogenetic trees and analyze clonal dynamics in early human embryogenesis.