APOBEC3A, not APOBEC3B, drives deaminase mutagenesis in human gastric epithelium
Yohan An, Ji‐Hyun Lee, Joonoh Lim, Jeonghwan Youk, Seongyeol Park, Ji‐Hyung Park, Kijong Yi, Tae‐Woo Kim, Chang Hyun Nam, Won Hee Lee, Soo Ah Oh, Yoo Jin Bae, Junehwak Lee, Jung Woo Park, Jie‐Hyun Kim, , Young Seok Ju
This study shows APOBEC3A, not APOBEC3B, causes significant mutagenesis in human gastric epithelium through whole-genome sequencing of organoids with inducible APOBEC3A or APOBEC3B.
bioRxiv · Oct 28, 2024 · PreprintGenomics