Samantha L. Bell

A single mycobacterial ligand organizes multi-receptor signaling to reprogram macrophage lipid metabolism

This paper shows that the mycobacterial ligand ManLAM uses structural features to engage TLR2 and Dectin-2, reprogramming macrophage lipid metabolism and promoting foam cell formation.

Mycobacterium tuberculosis effector protein PE5 hijacks the host CRL2 ubiquitin ligase complex

This paper identifies PE5, a Mycobacterium tuberculosis effector protein, as interacting with the host CRL2 ubiquitin ligase complex, modulating its activity without being ubiquitinated itself.