Jérôme Nigou

This study shows that PIM6 modulates innate immune responses in macrophages, reducing cytokine production and enhancing bacterial control during Mycobacterium tuberculosis infection.

The paper identifies a dynamic membrane platform in mycobacteria that coordinates protein-O-mannosylation and proteostasis through a hierarchically organized network.

This paper shows that the mycobacterial ligand ManLAM uses structural features to engage TLR2 and Dectin-2, reprogramming macrophage lipid metabolism and promoting foam cell formation.