A single mycobacterial ligand organizes multi-receptor signaling to reprogram macrophage lipid metabolism
Dhrubajyoti Nag, Joycelyn Radeny, Jin Cui, Omair Vehra, Yan. Ju Yu, Jérôme Nigou, Samantha L. Bell, Maria Laura Gennaro
This paper shows that the mycobacterial ligand ManLAM uses structural features to engage TLR2 and Dectin-2, reprogramming macrophage lipid metabolism and promoting foam cell formation.
bioRxiv · May 27, 2026 · PreprintMicrobiology