Markus Krane

Sequential defects in cardiac lineage commitment and maturation cause hypoplastic left heart syndrome

This study identifies sequential defects in cardiac lineage commitment and maturation in hypoplastic left heart syndrome using multi-omics approaches and iPSC modeling.

Genome-wide association study in European patients with congenital heart disease identifies risk loci for transposition of the great arteries and anomalies of the thoracic arteries and veins and expression of discovered candidate genes in the developing heart

This study identifies genetic risk loci for congenital heart disease subtypes and shows candidate genes play essential roles in heart development.

Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo

This study examines the dynamics of the cardiac myocyte epigenome during development and in chronic heart failure, revealing distinct epigenetic programs in health and disease.