Ralf Gilsbach

Transcriptional regulation of the TASK-1 potassium channel by ETV1 -Implications for atrial excitability

This study shows ETV1 directly regulates TASK-1 expression and contributes to atrial electrical remodelling, suggesting ETV1 as a potential therapeutic target for atrial fibrillation.

Selective class IIa HDAC inhibition reverses diastolic dysfunction in cardiometabolic HFpEF

This study shows that selective class IIa HDAC inhibition improves diastolic dysfunction in HFpEF without adverse effects.

The transaminase-omega-amidase pathway is a redox switch in glutamine metabolism that generates alpha-ketoglutarate

The paper identifies the transaminase-omega-amidase pathway as a redox-sensitive metabolic switch in endothelial glutamine metabolism, showing that NIT2 oxidation inhibits its activity and affects angiogenesis.

Long non-coding RNAs direct the SWI/SNF complex to cell-specific enhancers

This study identifies long non-coding RNAs (lncRNAs) as guides for the SWI/SNF complex to cell-specific enhancers, revealing a mechanism for chromatin accessibility and gene expression control.

In vivo silencing of regulatory elements using a single AAV-CRISPRi vector

This paper develops an AAV-based CRISPRi system to silence gene expression in cardiac myocytes, showing dose-dependent reduction of Nppa expression in vitro and in vivo.

HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex

The paper identifies HIF1α-AS1 as a DNA:DNA:RNA triplex-forming lncRNA that interacts with the HUSH complex to repress gene expression and modulates angiogenesis in pulmonary hypertension.

Sequential defects in cardiac lineage commitment and maturation cause hypoplastic left heart syndrome

This study identifies sequential defects in cardiac lineage commitment and maturation in hypoplastic left heart syndrome using multi-omics approaches and iPSC modeling.

Genome-wide association study in European patients with congenital heart disease identifies risk loci for transposition of the great arteries and anomalies of the thoracic arteries and veins and expression of discovered candidate genes in the developing heart

This study identifies genetic risk loci for congenital heart disease subtypes and shows candidate genes play essential roles in heart development.

The landscape of SARS-CoV-2 RNA modifications

This study uses direct RNA sequencing to identify RNA modifications in SARS-CoV-2 isolated from human lung cells, revealing conserved modification patterns across isolates.

Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo

This study examines the dynamics of the cardiac myocyte epigenome during development and in chronic heart failure, revealing distinct epigenetic programs in health and disease.