Lutz Hein

This study identifies sequential defects in cardiac lineage commitment and maturation in hypoplastic left heart syndrome using multi-omics approaches and iPSC modeling.

This study identifies genetic risk loci for congenital heart disease subtypes and shows candidate genes play essential roles in heart development.

This study shows that Eomes and Brachyury control pluripotency exit and germ layer segregation by altering chromatin states, with Tbx factors repressing pluripotency and NE gene programs while enabling ME differentiation.

This study examines the dynamics of the cardiac myocyte epigenome during development and in chronic heart failure, revealing distinct epigenetic programs in health and disease.