Roberta Bosotti

This study shows that COG5 deficiency disrupts Golgi organization and affects neural progenitor fate during human brain development through altered trafficking and glycosylation.

This paper identifies three glioblastoma stem cell morphoclasses using CellShape-seq, showing distinct functions and therapeutic vulnerabilities.

The paper maps RNA-DNA interactions in 16 human cell types, showing cell-type-specific and dynamic networks that correlate with gene regulation and disease traits.

The paper identifies transcriptionally distinct morphotypes of human basal radial glia and links their morphology, gene expression, and cell fate.

This study shows adducins regulate proliferation and fate of neural progenitors in mouse, ferret, and human neocortex, affecting neurogenesis.

The paper creates a breast cancer cell line atlas to study tumour heterogeneity and drug response by integrating single-cell data with bulk gene expression and drug screening results.