Matteo Bonfanti

R2T2P integrates transcriptomics and proteomics data to study FSHD, revealing novel RNAs and their impact on translation and protein levels.

This paper identifies three glioblastoma stem cell morphoclasses using CellShape-seq, showing distinct functions and therapeutic vulnerabilities.

The paper maps RNA-DNA interactions in 16 human cell types, showing cell-type-specific and dynamic networks that correlate with gene regulation and disease traits.

The paper identifies transcriptionally distinct morphotypes of human basal radial glia and links their morphology, gene expression, and cell fate.

The paper longitudinally profiles cerebellar organoids, benchmarks them against fetal data, and models mutations linked to autism and human brain evolution.

The paper develops and validates multiplexing strategies for brain organoids combined with single cell RNA-seq to study neurodevelopmental trajectories across multiple genetic lines.