Author

Tung T. Le

Howard Hughes Medical InstituteORCID 0000-0002-5481-4080Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Assay:proteomics· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

James T. InmaniD· 2 shared Michelle Dong WangiD· 2 shared Dirk RemusiD· 1 shared Dong WangiD· 1 shared Jaeyoon LeeiD· 1 shared Jin QianiD· 1 shared Lucyna Lubkowska· 1 shared Mikhail KashleviD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBiophysics

James T. InmanORCID

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2 papers

Recent·Most cited

RNA Polymerase II is a Polar Roadblock to a Progressing DNA Fork

Taryn M. Kay, James T. Inman, Lucyna Lubkowska, Tung T. Le, Jin Qian, Porter M. Hall, Sahil Batra, Dirk Remus, Dong Wang, Mikhail Kashlev, Michelle Dong Wang

This study investigates the polarity of RNA Polymerase II as a roadblock to DNA replication forks, showing that head-on collisions lead to stable binding and R-loop formation, with TFIIS facilitating hybrid removal.

Nature Communications · Sep 29, 2025Peer-reviewedBiophysics

An Effective Surface Passivation Assay for Single-Molecule Studies of Chromatin and Topoisomerase II

Tung T. Le, Xiang Gao, Seong ha Park, Jaeyoon Lee, James T. Inman, Michelle Dong Wang

This paper describes a surface passivation assay to reduce non-specific adsorption for single-molecule studies of chromatin and topoisomerase II.

STAR Protocols · Dec 17, 2024Peer-reviewedBiophysics