Xiang Gao

Torsion is a Dynamic Regulator of DNA Replication Stalling and Reactivation

This study develops a high-resolution assay to show that the replisome, composed of helicase and DNA polymerase, is a powerful torsional motor that regulates DNA replication stalling and reactivation.

An Effective Surface Passivation Assay for Single-Molecule Studies of Chromatin and Topoisomerase II

This paper describes a surface passivation assay to reduce non-specific adsorption for single-molecule studies of chromatin and topoisomerase II.

Tunable Elliptical Cylinders for Rotational Mechanical Studies of Single DNA Molecules

This paper introduces tunable elliptical cylinders for rotational mechanical studies of DNA, achieving higher rotation rates and improved torque measurement resolution compared to quartz cylinders.

A bone-derived protein primes rapid visual escape via GPR37 receptor in a subpopulation of VTA GABAergic neurons

This paper shows that osteocalcin primes rapid visual escape via GPR37 in VTA GABAergic neurons by reducing K+ currents through cAMP and THIK-1 suppression.

Optical Torque Calculations and Measurements for DNA Torsional Studies

This paper develops a numerical platform and experimental method to calculate and measure optical torque on DNA, showing agreement between simulations and measurements.