Mikhail Kashlev

This study shows that chromatin buffers torsional stress during transcription by enabling Pol II to transcribe through nucleosomes more efficiently than on single-nucleosome substrates.

The paper develops 5TNET-seq to study productive reiterative initiation in E. coli, finding it occurs in over 51% of promoters and is influenced by specific promoter regions and trinucleotide sequences.

This study investigates the polarity of RNA Polymerase II as a roadblock to DNA replication forks, showing that head-on collisions lead to stable binding and R-loop formation, with TFIIS facilitating hybrid removal.

The paper introduces TERMITe, a method for analyzing Term-seq data to identify bacterial transcription terminators and provides an atlas of validated termination sites across 13 species.

The paper estimates transcription fidelity in human cells, identifies factors controlling its accuracy, and links transcription errors to Alzheimer's disease progression.

The paper resolves a long-standing paradox about σ38 promoters in E. coli by showing they use two UP elements instead of a -35 element and transcribe ribosomal promoters.