Jared T. Nordman

Nup98 regulates the G1/S transition

The paper shows Nup98 regulates the G1/S transition in Drosophila by promoting S phase entry, with a dominant-negative effect when overexpressed.

NASP functions in the cytoplasm to prevent histone H3 aggregation during early embryogenesis

This study shows NASP prevents H3 aggregation in the cytoplasm, indirectly protecting H3 from degradation during early Drosophila embryogenesis.

Nanopore-based sequencing of active DNA replication reveals key principles of metazoan replication fork progression, origin and termination sites

The paper uses nanopore sequencing and DNAscent to measure replication fork progression and origin/termination sites in Drosophila, revealing non-uniform fork speeds and variable origin positions.

BRWD3 promotes KDM5 degradation to maintain H3K4 methylation levels

This study shows BRWD3 promotes KDM5 degradation, which maintains H3K4 methylation levels by balancing H3K4me1 and H3K4me3.

The histone chaperone NASP maintains H3-H4 reservoirs in the early Drosophila embryo

This study identifies NASP as the critical H3-H4 histone chaperone in the Drosophila embryo, showing that its absence leads to degradation of soluble H3-H4 pools and embryonic defects.

Nucleoporins facilitate ORC loading onto chromatin

The paper shows that nucleoporins, specifically Elys, are required for ORC2 loading onto chromatin and proper replication initiation in Drosophila.

R-loop mapping and characterization during Drosophila embryogenesis reveals developmental plasticity in R-loop signatures

The paper maps and characterizes R-loops during Drosophila embryogenesis, showing developmental plasticity in their abundance and localization without changes in transcriptional program.

Replication timing analysis in polyploid cells reveals Rif1 uses multiple mechanisms to promote underreplication in Drosophila.

The paper shows Rif1 promotes underreplication in Drosophila polyploid cells through both upstream and downstream roles relative to SUUR in controlling replication timing.

Rif1 functions in a tissue-specific manner to control replication timing through its PP1-binding motif

This study shows that cell lineage primarily determines replication timing, while Rif1, through its PP1-binding motif, fine-tunes RT in a tissue-specific manner in Drosophila.

Rif1 inhibits replication fork progression and controls DNA copy number in Drosophila

The paper identifies Rif1 as a regulator of replication fork progression in Drosophila, acting downstream of SUUR to inhibit fork progression and control DNA copy number.