Bruce A. Hay

Quantitative measurement of synthetic repression curves reveals design challenges for genetic circuit engineering under growth arrest

The paper measures repression curves of genetic NOT gates in E. coli under growth and arrest conditions, finding growth arrest reduces unrepressed expression by >100-fold.

The LAST mile: Evaluating genetic biocontrol as a supplemental tool for eradicating invasive rodents on islands

This study evaluates genetic biocontrol methods as supplements to toxicant-based eradication of invasive rodents on islands, finding Gravid Lethal to be effective under certain strategies.

Cleave and Rescue gamete killers create conditions for gene drive in plants

The paper demonstrates the function of Cleave and Rescue (ClvR) gene drive in Arabidopsis thaliana by showing it kills gametes lacking the drive, and models its robustness for population modification.

Allele Sails: launching traits and fates into wild populations with DNA sequence modifiers

The paper proposes Allele Sails, a population-scale gene editing system that uses Mendelian inheritance of editors and Super-Mendelian spread of edits to alter wild population traits without transgenic persistence.

Gene drive that results in addiction to a temperature sensitive version of an essential gene triggers population collapse in Drosophila

The paper demonstrates that a temperature-sensitive gene drive in Drosophila causes population collapse when temperature shifts trigger lethality and sterility.

2-Locus ​ Cleave and Rescue ​ selfish elements harness a recombination rate-dependent generational clock for self limiting gene drive

The paper demonstrates that 2-locus Cleave and Rescue elements create self-limiting gene drive, with spread controlled by a recombination rate-dependent generational clock in Drosophila.

A novel drug-inducible sex-separation technique for insects

This paper introduces a drug-inducible system for sex separation in insects, demonstrating 100% efficiency in Drosophila melanogaster with low fitness costs.

Gene drive and resilience through renewal with next generation Cleave and Rescue selfish genetic elements

This paper introduces Cleave and Rescue (ClvR) selfish genetic elements that enable cyclic population modification in Drosophila by overwriting genetic content while eliminating old elements.

Behavior of homing endonuclease gene drives targeting genes required for viability or female fertility with multiplexed guide RNAs

This paper tests a gene drive strategy using multiple guide RNAs to prevent resistance alleles but finds issues with homing rates and fitness costs.