Tobin Ivy

The paper demonstrates the function of Cleave and Rescue (ClvR) gene drive in Arabidopsis thaliana by showing it kills gametes lacking the drive, and models its robustness for population modification.

The paper demonstrates that a temperature-sensitive gene drive in Drosophila causes population collapse when temperature shifts trigger lethality and sterility.

The paper demonstrates that 2-locus Cleave and Rescue elements create self-limiting gene drive, with spread controlled by a recombination rate-dependent generational clock in Drosophila.

This paper introduces Cleave and Rescue (ClvR) selfish genetic elements that enable cyclic population modification in Drosophila by overwriting genetic content while eliminating old elements.

This paper tests a gene drive strategy using multiple guide RNAs to prevent resistance alleles but finds issues with homing rates and fitness costs.