The extracellular matrix protein agrin is essential for epicardial epithelial-to-mesenchymal transition during heart development
Xin Sun, Sophia Malandraki-Miller, Tahnee L. Kennedy, Elad Bassat, Konstantinos Klaourakis, Jia Zhao, Elisabetta Gamen, Joaquim Miguel Vieira, Eldad Tzahor, Paul Richard Riley
This study identifies agrin as a critical regulator of epicardial EMT by localizing dystroglycan to the Golgi apparatus, ensuring ECM-cytoskeletal connectivity and mechanical integrity during heart development.
Development · May 1, 2021Peer-reviewedDevelopmental Biology