Paul Richard Riley

The paper investigates organ-specific fibroblast dynamics in cardiac and pulmonary fibrosis using experimental and computational methods, revealing differences in collagen matrix organization and motility behavior.

The paper identifies distinct roles of the Lyve1 lineage in heart development, showing its contribution to multiple cardiovascular cell types and demonstrating functional consequences of genetic perturbations.

The paper identifies epigenetic regulators of fibrotic transformation in cardiac fibroblasts using bulk and single-cell CRISPR screens and shows KAT5 inhibition reduces fibrotic responses in human fibroblasts.

This study identifies two progenitor sources for kidney lymphatics in mice: Tie2 endothelial lineage and Osr1 intermediate mesoderm, showing a dual origin for kidney lymphatic formation.

The paper adapts the Ac/Ds transposition system to enable CRISPR/dCas9 interference for studying non-coding RNAs and enhancers in zebrafish without altering genetic sequences.

This study identifies a direct origin of lymphatic endothelial cells from non-venous angioblasts, challenging the prevailing view that they primarily derive from venous endothelium.

The paper identifies molecular markers for placental arterial and venous endothelial cells and shows maternal iron deficiency impairs the arterial vascular network.

This study identifies Prrx1b's role in directing pro-regenerative fibroblasts during zebrafish heart regeneration, reducing fibrosis and promoting tissue repair.

The paper identifies distinct gene regulatory programmes in the zebrafish epicardium during development and regeneration, revealing differences from developmental programmes.

This study identifies agrin as a critical regulator of epicardial EMT by localizing dystroglycan to the Golgi apparatus, ensuring ECM-cytoskeletal connectivity and mechanical integrity during heart development.

This study shows that tissue-resident macrophages are essential for lymphatic vessel growth and patterning during heart development by remodeling the vascular plexus.

This study shows that Runx1 inhibits heart regeneration in zebrafish by promoting scar formation and reducing myocardial proliferation and survival.

This study identifies three distinct epicardial subpopulations in developing zebrafish hearts using single-cell RNA-sequencing and reveals their unique functions in cell adhesion, migration, and leukocyte recruitment.