Andrew Mugler

Colony morphogenesis regulates sporulation dynamics in bacterial biofilms

This study shows that colony expansion and sporulation dynamics in Bacillus subtilis biofilms are interdependent, with sporulation waves driving dormancy while non-sporulating cells maintain expansion.

Fast, long-range intercellular signal propagation through growth assisted positive feedback

The paper constructs and tests synthetic circuits in E. coli to show that positive feedback-regulated secondary signals can propagate faster and farther than diffusion-limited signals.

Bacterial population dynamics during colonization of solid tumors

This study investigates bacterial population dynamics in murine tumors, revealing nonuniform growth and a scale-free distribution of bacterial clone sizes.

Decay in transcriptional information flow is a hallmark of cellular aging

The paper quantifies age-related decline in transcriptional information flow using information theory and single-cell RNA-seq data, finding reduced mutual information between transcription factors and target genes.

Precise temporal control of neuroblast migration through combined regulation and feedback of a Wnt receptor

The paper studies a timing mechanism in C. elegans neuroblast migration using a Wnt receptor, showing that non-linear upregulation and positive feedback enhance temporal precision.

Sensitivity to perturbations of a cell migration under temporal regulation

This study examines how external perturbations and genetic variation affect the final position of QR.pax cells during migration in C. elegans.