Longitudinal single-cell RNA sequencing of a neuroendocrine transdifferentiation model reveals transcriptional reprogramming in treatment-induced neuroendocrine prostate cancer
Funda Sar, Hee Chul Chung, Yen‐Yi Lin, Dong Lin, Tunç Morova, Anne M. Haegert, Stanislav V. Volik, Robert H. Bell, Stéphane LeBihan, Doğancan Özturan, Hui Xie, Xin Dong, Rebecca Wu, Jing Li, Hsing‐Jien Kung, , Colin C. Collins
This study uses longitudinal scRNA-seq to track neuroendocrine transdifferentiation in a prostate cancer model, identifying transcriptional changes and key regulators during treatment-induced NEPC progression.
Genome Medicine · Oct 28, 2026Peer-reviewedCancer Biology