Qiangqiang Wang

This study shows that dimethyl fumarate (DMF) enhances antitumor immunity in cervical cancer by reprogramming tumor cells to activate the mtDNA-cGAS-STING pathway, increasing CD8+ T cell infiltration.

This study identifies CHMP2B as a regulator of TDP-43 phosphorylation and proteotoxicity through CK1 turnover, independent of autophagy-lysosomal pathways in neurodegenerative diseases.

The paper shows stress induces TDP-43 nuclear bodies via NEAT1-promoted phase separation, which protects cells from toxicity and is disrupted by an ALS mutation.