Stress induces cytoprotective TDP-43 nuclear bodies through lncRNA NEAT1-promoted phase separation
Chen Wang, Yongjia Duan, Gang Duan, Qiangqiang Wang, Kai Zhang, Xue Deng, Beituo Qian, Jinge Gu, Zhiwei Ma, Shuang Zhang, Lin E. Guo, Cong Liu, Yanshan Fang
The paper shows stress induces TDP-43 nuclear bodies via NEAT1-promoted phase separation, which protects cells from toxicity and is disrupted by an ALS mutation.
Molecular Cell · Jul 9, 2020Peer-reviewedNeuroscience